Faculty

silver

Roy L. Silverstein, M.D.

Chairman

  • Role of CD36 in platelet function
  • CD36 signaling in vascular cells
  • Regulation of angiogenesis by TSR containing proteins

Martha K. Cathcart, Ph.D.

Staff

  • Human monocyte activation
  • Respiratory burst activation
  • Lipid oxidation
  • Signal transduction
  • Lipoprotein oxidation

Paul E. DiCorleto, Ph.D.

Staff, Chairman of the Lerner Research Institute
  • Regulation of Endothelial Cell Gene Expression
  • TNF-a Signaling through TNF receptor 2 in Endothelial Cells
  • Role of Homeobox Gene HOXA9 in Endothelial Cell Activiation
  • MAP Kinase Phosphatase-1 in EC signaling

Donna M. Driscoll, Ph.D.

Staff
  • Posttranscriptional regulation of gene expression
  • RNA structure and function

Dr. Egelhoff

Thomas Egelhoff, Ph.D.

Staff
  • Cytoskeletal mechanics of cell migration
  • Regulation of cell division machinery
  • Cancer cell migration
  • Keratinocyte wound healing

Ariel Feldstein

Ariel Feldstein, M.D.

Staff
  • The liver in obesity and type 2 diabetes 
  • Mechanisms of lipotoxicity
  • Mechanisms of inflammation and fibrogenesis during chronic liver injury
  • Lipid homeostasis and liver carcinogenesis

Paul L. Fox, Ph.D.

Staff
  • Endothelial cell motility
  • Cellular oxidation processes
  • Ceruloplasmin

hazen

Stanley L. Hazen, M.D., Ph.D.

Staff
  • Leukocyte peroxidases
  • Free radicals and reactive oxygen species
  • Oxidative damage of biomolecules in disease

Donald W. Jacobsen, Ph.D.

Staff
  • Homocysteine as a modifiable risk factor for cardiovascular disease
  • Vascular cell metabolism of homocysteine and gene-nutrient interactions
  • Homocysteine-induced gene expression in vascular cells
  • Vascular biochemistry of vitamin B12

Dr. Janigro

Damir Janigro, Ph.D.

Staff
  • Epilepsy
  • Blood Brain Barrier

Andrea N. Ladd, Ph.D.

Assistant Staff
  • Pre-mRNA alternative splicing regulation in vertebrate heart and muscle development

Mccrae

Véronique Lefebvre, Ph.D.

Associate Staff
  • Transcriptional control of cell fate and differentiation

Mccrae

Keith McCrae, M.D.

Staff
  • Mechanisms of endothelial cell activation in the antiphospholipid syndrome
  • Regulation of angiogenesis by kininogen and kininogen-derived peptides
  • Characterization and activities of circulating microparticles

McIntyre

Thomas M. McIntyre, Ph.D.

Staff
  • Identify novel inflammatory lipids and characterize the signaling systems they activate
  • Explore intracellular signaling by lysophosphatidic acid
  • Purify the enzyme that synthesizes PAF
  • Purify and clone novel enzymes that degrade PAF

Richard E. Morton, Ph.D.

Staff
  • Lipid and lipoprotein metabolism
  • Membrane structure-function relationships
  • Lipid-protein interactions

Ofer Reizes, Ph.D.

Associate Staff
  • Role of syndecans in energy balance and obesity
  • Mechanisms underlying and adipose tissue resistance to weight loss

Jonathan D. Smith, Ph.D.

Staff
  • Macrophage cholesterol metabolism
  • Genetics of atherosclerosis susceptibility in mouse models
  • Genetics and drug discovery in mouse models of Alzheimer disease

Alan J. Zhu, Ph.D.

Assistant Staff
  • Hedgehog signaling
  • Vesicle trafficking
  • Cytoskeletal dynamics

Staff Scientist

Project Scientists

Research Associates

Joint Appointments

  • Bela Anand-Apte, MBBS, Ph.D. (Primary w/ Cole Eye Institute)
  • Jay Ciezki, M.D. (Primary w/ Radiation Oncology)
  • John W. Crabb, Ph.D. (Primary w/ Eye Institute)
  • Joe G. Hollyfield, Ph.D. (Primary w/ Eye Institute)
  • Vikram Kashyap, M.D. (Primary w/Vascular Surgery)
  • Stephen Nicholls, M.D. (Primary w/Cardiovascular Medicine)
  • Jonathan Sears, M.D. (Primary w/ Eye Institute)
  • Wai Hong Wilson Tang, M.D. (Primary w/Cardiovascular Medicine)

Adjunct Appointments

  • G. Valentin Boerner, Ph.D. (Cleveland State University)
  • Nicola Brasch, Ph.D. (Kent State University)
  • Stanley Duraj, Ph.D. (Cleveland State University)
  • Valentin Gogonea, Ph.D. (Cleveland State University)
  • Kurt Lu, M.D. ( Case Western Reserve University)
  • Barsanjit Mazumder, Ph.D. (Cleveland State University)
  • Gopal Marathe, Ph.D. (Univ. of Mysore Manasagangothri)
  • Lily M. Ng, Ph.D. (Cleveland State University)
  • Andrew Resnick, Ph.D (Cleveland State University)
  • Gerald M. Saidel, Ph.D. (Case Western Reserve University)
  • William P. Schilling, Ph.D. (MetroHealth Medical Center)
  • Crystal Weyman, Ph.D. (Cleveland State University)

Consultants